Cisplatin atherosclerosis

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August undefined, 2024

WebJul 29, 2024 · The cancer-therapeutic drug, cisplatin, induces the release of GDF15 and activates GFRAL AP/NTS neurons, as well as causing significant reductions in food intake and body weight in mice. These … WebStatins were associated with slower progression of overall coronary atherosclerosis volume, with increased plaque calcification and reduction of high-risk plaque …

Cisplatin (Cisplatin Injection): Uses, Dosage, Side Effects ... - RxList

WebDec 16, 2024 · Introduction: Cisplatin-based chemotherapeutic regimen (CBCR) is known for increasing risk of venous thromboembolic (TE) disease. We report a unique case of STEMI associated with CBCR which we believe was caused by coronary artery … WebAcute clinical syndromes associated with cisplatin infusion include chest pain, palpitations, and, occasionally, elevated cardiac enzymes indicative of myocardial … chin fighter and the kid

Toxicities Associated with Cisplatin-Based Chemotherapy and ...

WebRecently, a genome-wide analysis of cisplatin-induced peripheral neuropathy in survivors of adult-onset cancer reported that genetically determined expression level of RPRD1B … WebIn addition, BANCR induced the proliferation of vascular smooth muscle cells by downregulating miR-34c methylation in atherosclerosis. 34 Here, we could not exclude the possibility that BANCR may attenuate the killing capacity of cisplatin on GC cells by regulating miRNAs. Further investigation is needed in our future study. WebAtherosclerosis is characterized by vascular obstruction from the deposits of plaque, resulting in reduced blood flow. Plaque rupture and the consequent thrombosis may lead to sudden blockage of the arteries and cause heart attack. chin filler near me

Cisplatin related cardiotoxicity – acute and chronic …

National Center for Biotechnology Information

WebDec 30, 2024 · However, cardiovascular toxicity is a major concern. In addition to acute endothelial toxicity and associated risk of arterial thrombosis, accelerated atherosclerosis may be the result of chemotherapy-associated latent cardio-metabolic dysfunction. A 45-year-old man began treatment with cisplatin-based chemotherapy for testicular cancer. WebMar 24, 2024 · Having an atherosclerosis-related disease may cause fear, anxiety, depression, and stress. You may worry about having heart problems or making lifestyle changes that are necessary for your health. Talk with your healthcare team about how you feel and actions you can take. Talk to a counselor. granger hobby townWebJan 11, 2024 · High risk for progression includes those with a large plaque burden, a thin-cap fibroatheroma, low-attenuation, and positive vessel remodeling. Among patients with … chin falan

"WebAug 14, 2024 · Lipopolysaccharide (LPS) is an endotoxin that induces systemic inflammatory responses. Melittin, a main constituent of bee venom, exerts several biological activities such as antioxidant, anti-inflammatory, and antiapoptotic actions. However, whether melittin protects against endotoxin-induced AKI remains undetermined. " - Cisplatin atherosclerosis

Cisplatin atherosclerosis

National Center for Biotechnology Information

Web2 days ago · Radiation therapy (RT) significantly increased the incidence of coronary artery diseases, especially atherosclerosis. Endothelial dysfunction has been the major side effect of RT among tumor patients who received RT. However, the involvement between endothelial dysfunction and radiation-induced atherosclerosis (RIA) remains unclear. WebTherefore, selective inhibition of CaMKIIγ in lesional macrophages holds great promise for the treatment of advanced atherosclerosis. We recently developed a siRNA NP platform that can selectively silence CaMKIIγ in macrophages, resulting in increased plaque stability.

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WebJun 27, 2014 · A 52-year-old executive was referred to our clinic for risk factor management after undergoing coronary computed tomography angiography (CTA) as part of an … WebApr 14, 2024 · Histone acetylation plays a vital role in organizing chromatin, regulating gene expression and controlling the cell cycle. The first histone acetyltransferase to be identified was histone acetyltransferase 1 (HAT1), but it remains one of the least understood acetyltransferases. HAT1 catalyzes the acetylation of newly synthesized H4 and, to a …

WebNational Center for Biotechnology Information WebMar 27, 2024 · Cisplatin (CisPt) is an alkylating drug that has been successfully used for decades to treat solid organ tumours such as lung, testis or ovarian cancers, resulting in an increased life expectancy for patients.

WebSep 15, 2024 · DESCRIPTION. Cisplatin Injection (cisplatin injection (cisplatin (cisplatin injection) injection) ) is a sterile aqueous solution, available in 50, 100 and 200 mL … Web2 days ago · Radiation therapy (RT) significantly increased the incidence of coronary artery diseases, especially atherosclerosis. Endothelial dysfunction has been…

WebFeb 1, 2024 · Cis-diamminedichloroplatinum (cisplatin) is an effective agent for treating solid tumors. However, its clinical use is limited by its serious toxic side effects; …

WebModern hypotheses introduce atherosclerosis as an inflammatory/lipid-based disease and NLRP3 inflammasome has been considered as a link between lipid metabolism and inflammation because crystalline cholesterol and oxidized low-density lipoprotein (oxLDL) (two abundant components in atherosclerotic plaques) activate NLRP3 inflammasome. granger high school wrestlingWebNational Center for Biotechnology Information chin fat removalWebOct 11, 2024 · Weakening of the heart muscle (cardiomyopathy) Heart rhythm problems (arrhythmia) Heart attack Stroke High blood pressure Blood clots Whether you're at risk … granger heatingWebNov 5, 2024 · Since its introduction in the late 1970s, cisplatin-based chemotherapy (CBCT) has revolutionized the treatment of metastatic testicular cancer (TC) and … granger hobby shopWebAug 13, 2024 · Cisplatin was dissolved in dimethylformamide, and other chemicals were dissolved in dimethyl sulfoxide (DMSO) upon receipt. All chemicals were aliquoted and stored at −80 °C. Cell culture The... chin filler cost ukWebOct 6, 2024 · The potential exists to alter the course of atherosclerosis with anti-inflammatory drugs. With increased understanding of the specific mechanisms that … granger hospital beaconWebJul 1, 2024 · Atherosclerosis is a specific type of arteriosclerosis. Atherosclerosis is the buildup of fats, cholesterol and other substances in and on the artery walls. This buildup is called plaque. The plaque can … chin filler projection