Citron homology

WebHomology more Human Ortholog CIT, citron rho-interacting serine/threonine kinase Vertebrate Orthologs 3 Human Diseases more Diseases 1 with human CIT associations Mutations, Alleles, and Phenotypes less Phenotype Summary 26 phenotypes from 2 alleles in 2 genetic backgrounds 24 phenotype references Phenotype Overview Webcitron homology (CNH) domain of unknown function that is found in many other eukaryotic genes. Here, we show that the Rom2 CNH domain interacts directly with …

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WebFeb 27, 2024 · C. elegans MRCK1 consists of an N-terminal CHB domain that mediates kinase domain dimerization, 28 followed by a region of predicted coiled-coil and C-terminal C1, pleckstrin homology (PH), and citron homology (CNH) domains of unknown structure and function (Figure 1 A). A Cdc42 and Rac-interactive binding (CRIB) motif is encoded … WebNov 15, 2011 · The predicted structure of Gek includes a serine/threonine kinase (STK) catalytic domain, a coiled-coil (CC) domain, a cysteine-rich region (CR), a pleckstrin homology (PH) domain, a citron homology (CH) domain and a Cdc42/Rac interactive binding (CRIB) domain (Luo et al., 1997) (supplementary material Fig. S1). the paper studio planner refills https://atucciboutique.com

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WebNov 6, 1998 · We have identified a novel serine/threonine kinase belonging to the myotonic dystrophy kinase family. The kinase can be produced in at least two different isoforms: a approximately 240-kDa protein (Citron Rho-interacting kinase, CRIK), in which the kinase domain is followed by the sequence of Citron, a previously identified Rho/Rac binding … WebJul 9, 2001 · Here, we report the identification of a novel human protein, hVam6p, that promotes lysosome clustering and fusion in vivo. Although hVam6p exhibits homology to the Saccharomyces cerevisiae vacuolar protein sorting gene product Vam6p/Vps39p, the presence of a citron homology (CNH) domain at the NH 2 terminus is unique to the … the paper studio paper pads

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Category:Human Vam6p promotes lysosome clustering and fusion in vivo

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Citron homology

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WebMay 26, 1998 · This region [“citron-homology” (CNH) domain] was identified as being homologous to the mouse Rho GTP /Rac GTP-binding protein, citron and to the C … Citron is a 183 kDa protein that contains a C6H2 zinc finger, a PH domain, and a long coiled-coil forming region including 4 leucine zippers and a rho / rac binding site. It was discovered as a rho/rac effector in 1995, interacting only with the GTP bound forms of rho and rac 1. Displaying a distinctive protein organization, this protein defines a separate class of rho partners. Using a cloning approach based on the polymerase chain reaction (PCR), a splice variant of citron, citro…

Citron homology

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WebBoth phosphorylation of Ser-348 and BLUS1 kinase activity are essential for activation of the H (+)-ATPase. blus1 mutants show lower stomatal conductance and CO2 assimilation than wild-type plants under decreased ambient CO2. Together, our analyses demonstrate that BLUS1 functions as a phototropin substrate and primary regulator of stomatal ... WebNov 19, 2004 · TNIK possesses an N-terminal kinase domain homologous to STE20, the Saccharomyces cerevisiae mitogen-activated protein kinase kinase kinase kinase, and …

WebNational Center for Biotechnology Information WebMar 2, 2024 · Another important region identified was the citron homology domain located at the end of the protein. Through fluorescent imaging, it was discovered that this domain …

WebCitron homology (CNH) domain CRIB domain KELK-motif containing domain Myotonic dystrophy protein kinase, coiled coil PH-like domain superfamily Pleckstrin homology … WebJul 9, 2001 · Here, we report the identification of a novel human protein, hVam6p, that promotes lysosome clustering and fusion in vivo. Although hVam6p exhibits homology to the Saccharomyces cerevisiae vacuolar protein sorting gene product Vam6p/Vps39p, the presence of a citron homology (CNH) domain at the NH(2) terminus is unique to the …

WebApr 16, 2004 · The CNH domain was originally found in citron that interacts with Rho and Rac . Subsequently, it was found in Rom2p, a GDP/GTP exchange factor for S. …

WebComparison Matrix. Gene Expression + Phenotype. Homozygotes for a null mutation are 20% smaller than wild-type and exhibit tremors, ataxia, and fatal seizures. Brains of … shuttle dublin airportWebJul 9, 2001 · Here, we report the identification of a novel human protein, hVam6p, that promotes lysosome clustering and fusion in vivo. Although hVam6p exhibits homology … shuttle duluth to msp airportWebMar 2, 2024 · This protein is localized to the plasma membrane by means of the citron homology domain, where the middle region binds to CK2, thus preventing it from phosphorylating PTEN. This activated PTEN downregulates phosphatidylinositol (3,4,5)-trisphosphate, an important driving factor of AKT signaling. Reduced AKT signaling leads … shuttle dtw to ann arborWebMay 1, 2005 · Hematopoietic progenitor kinase 1 (HPK1 or MAP4K1) is a hematopoietic-specific mammalian STE20-like protein serine/threonine kinase, comprised of a STE20 … shuttle ebayWebJournal: Proceedings of the National Academy of Sciences of the United States of America Article Title: The citron homology domain as a scaffold for Rho1 signaling doi: … shuttle duluth to mspWebMembers of this subfamily contain an N-terminal catalytic domain and a C-terminal citron homology (CNH) regulatory domain. MAP4K4 is also called Nck Interacting kinase (NIK). It facilitates the activation of the MAPKs, extracellular signal-regulated kinase (ERK) 1, ERK2, and c-Jun N-terminal kinase (JNK), by phosphorylating and activating MEKK1. shuttle dulles to dcWebNov 3, 2010 · GCK proteins are characterized by an N-terminal kinase domain and a C-terminal citron homology (CNH) domain separated by a variable region of lower sequence homology (Dan et al., 2001). MINK and TNIK specifically bind to Rap2 via their CNH domains ( Taira et al., 2004 ; Nonaka et al., 2008 ). shuttle eagle to aspen