Graph-linked unified embedding
WebMulti-omics single-cell data integration and regulatory inference with graph-linked embedding. ZJ Cao, G Gao. Nature Biotechnology 40 (10), 1458-1466, 2024. 54: ... WebAug 22, 2024 · bioRxiv.org - the preprint server for Biology
Graph-linked unified embedding
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WebMay 2, 2024 · Hereby, we introduce GLUE (graph-linked unified embedding), a modular framework for integrating unpaired single-cell multi-omics data and inferring regulatory … WebMay 2, 2024 · See new Tweets. Conversation
WebJan 27, 2024 · To learn comprehensive representations based on such modality-incomplete data, we present a semi-supervised neural network model called CLUE (Cross-Linked Unified Embedding). Extending from... WebMay 19, 2024 · A new study presents GLUE (graph-linked unified embedding), a generalizable computational framework for integrating unpaired single-cell multi …
WebMulti-omics integration and regulatory inference for unpaired single-cell data with a graph-linked unified embedding framework 2024-08-24 Other DOI: 10.1101/2024.08.22.457275 Contributors : Zhi-Jie Cao; Ge Gao Show more detail Source : Crossref Searching large-scale scRNA-seq databases via unbiased cell embedding with Cell BLAST We assume that there are K different omics layers to be integrated, each with a distinct feature set \({{{\mathcal{V}}}}_k,k = 1,2, \ldots ,K\). For example, in scRNA-seq, \({\mathcal{V}}_k\) is the set of genes, while in scATAC-seq, \({{{\mathcal{V}}}}_k\) is the set of chromatin regions. The data … See more As shown in previous work31, canonical adversarial alignment amounts to minimizing a generalized form of Jensen–Shannon divergence among the cell embedding distributions of different omics layers: where … See more We applied linear dimensionality reduction using canonical methods such as PCA (for scRNA-seq) or LSI (latent semantic indexing, for scATAC … See more To handle batch effect within omics layers, we incorporate batch as a covariate of the data decoders. Assuming \(b \in \left\{ {1,2, \ldots ,B} \right\}\), is the batch index, where B is the total number of batches, the decoder … See more The integration consistency score is a measure of consistency between the integrated multi-omics data and the guidance graph. First, we jointly cluster cells from all omics layers in the aligned cell embedding … See more
WebThis section provides detailed API documentation for all public functions and classes in scglue. scglue GLUE (Graph-Linked Unified Embedding) . Read the Docs
WebThe scglue package can be installed via conda using one of the following commands: conda install -c conda-forge -c bioconda scglue # CPU only conda install -c conda-forge -c … earring box argosWebGraph embedding is a way to transform and encode data structure in high dimensional and Non-Euclidean feature space to a low dimensional and structural space. We have … ct apportionmentWebSep 6, 2024 · With the ever-increasing amount of single-cell multi-omics data accumulated during the past years, effective and efficient computational integration is becoming a … ct application for reservation of nameWebDescription. Graph-linked unified embedding for single-cell multi-omics data integration cta print swanseaWebMay 2, 2024 · Here, we propose a computational framework called GLUE (graph-linked unified embedding), which bridges the gap by modeling regulatory interactions across omics layers explicitly. Systematic benchmarking demonstrated that GLUE is more accurate, robust and scalable than state-of-the-art tools for heterogeneous single-cell multi-omics … ct aprn license lookupWebMay 1, 2024 · A new study presents GLUE (graph-linked unified embedding), a generalizable computational framework for integrating unpaired single-cell multi-omics … ct appliances repair \u0026 installationWebFeb 3, 2024 · Graph embeddings are calculated using machine learning algorithms. Like other machine learning systems, the more training data we have, the better our embedding will embody the uniqueness of an item. The process of creating a new embedding vector is called “encoding” or “encoding a vertex”. cta premium locking wall mount - bracket