WebIsoforms of the smooth muscle myosin phosphatase targeting subunit 1 (MYPT1) are generated by cassette- type alternative splicing of exons. Tissue-specific ex- pression of these isoforms is thought to determine smooth muscle-relaxant properties and unique re- sponses to signaling pathways. WebAug 1, 2011 · An isoform of MYPT1 that lacks the C-terminal LZ motif is generated by the alternative splicing of a 31 nt 3’ exon (E23). We have shown that the expression of these …
Characterization of isoform expression and subcellular …
WebSep 21, 2024 · Splicing of the MYPT1 3' alternative exon and the MLC(17) alternative exon were unaffected, suggesting that TIA proteins regulate a subset of smooth muscle/nonmuscle alternative splicing reactions. WebMar 14, 2003 · Isoforms of the smooth muscle myosin phosphatase targeting subunit 1 (MYPT1) are generated by cassette-type alternative splicing of exons. Tissue-specific … moab over thanksgiving
Splicing of a Myosin Phosphatase Targeting Subunit 1 …
WebThe myosin phosphatase targeting protein (MYPT) family: a regulated mechanism for achieving substrate specificity of the catalytic subunit of protein phosphatase type 1delta. Arch Biochem Biophys. 2011;510:147–159. [ PubMed] [ Google Scholar] 26. … WebMay 10, 2004 · Initially MYPT1 was cloned from chicken gizzard (M130/M133 (8)) and also from rat aorta (rat3 isoform (9)). Structure of MYPT1 From the initial reports the basic features of the MYPT1 mole-cule were established. The molecule is hydrophilic, and no exten-sive hydrophobic patches are found. Plans of human and chicken MYPT1 are … WebNov 4, 2024 · Alternative splicing of exon 24 (E24) of the myosin phosphatase regulatory subunit (Mypt1) tunes smooth muscle sensitivity to NO/cGMP-mediated vasorelaxation and thereby controls blood pressure (BP) in otherwise normal mice. This occurs via the toggling in or out of a C-terminal leucine zipper (LZ) motif required for hetero-dimerization with and … injection dissolves fat